纳米塑料诱导肺泡Ⅱ型上皮细胞DNA损伤加重重症哮喘

施泽纶, 王青, 何雯, 傅唯佳, 王颖雯, 韩晓, 张晓波

Nanoplastics aggravate severe asthma by inducing DNA damage of alveolar type Ⅱ epithelial cells

SHI Zelun, WANG Qing, HE Wen, FU Weijia, WANG Yingwen, HAN Xiao, ZHANG Xiaobo

图8 Ceralasertib对PS-NPs诱导的AT2细胞增殖、凋亡的恢复作用 Note： A. Ceralasertib restores the proliferation of AT2 cells after 0, 24 or 48 h. B/C. Ceralasertib restores the apoptosis rate of AT2 cells induced by PS-NPs. ①P=0.010, compared with the PS-NPs (20 μg·mL-1) group; ②P=0.001, ③P<0.001, compared with the control group; ④P<0.001, compared with the PS-NPs (10 μg·mL-1) group.

Fig 8 Ceralasertib restores the effects induced by PS-NPs on proliferation and apoptosis of AT2 cells