基于生理药物代谢动力学模型预测氯氮平联合用药的药物相互作用

牟凡, 黄志伟, 程渝, 赵雪, 李华芳, 禹顺英

Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying

图2 患者多次口服氯氮平片后的药时曲线 Note： A. Plasma concentration-time curve profiles of clozapine after the administration of multiple 150 mg oral tablets in patients. B. Plasma concentration-time curve profiles of clozapine after the administration of multiple 100 mg oral tablets in patients.

Fig 2 Plasma concentration-time curve profiles of clozapine after the administration of multiple oral tablets of clozapine in patients