基于生理药物代谢动力学模型预测氯氮平联合用药的药物相互作用

牟凡, 黄志伟, 程渝, 赵雪, 李华芳, 禹顺英

Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying

图3 健康受试者单次50 mg口服氟伏沙明后的药时曲线及残差 Note： A. Plasma concentration-time curve profiles of fluvoxamine after the administration of a single 50 mg dose of fluvoxamine in healthy adults. B. Residue plot for the model prediction of fluvoxamine plasma concentrations in healthy adults.

Fig 3 Plasma concentration-time curve profiles and residue plot of fluvoxamine after the administration of a single 50 mg dose of fluvoxamine in healthy adults