基于生理药物代谢动力学模型预测氯氮平联合用药的药物相互作用

牟凡, 黄志伟, 程渝, 赵雪, 李华芳, 禹顺英

Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying

图4 氯氮平-氟伏沙明合用前后氯氮平的药时曲线的比较 Note： A. Plasma concentration-time curve profiles of clozapine (100 mg) before and after combination with fluvoxamine (50 mg). B. Plasma concentration-time curve profiles of clozapine (150 mg) before and after combination with fluvoxamine (50 mg). bid—twice a day; qd—once a day.

Fig 4 Comparison of plasma concentration-time curve profiles of clozapine before and after combination with fluvoxamine