基于生理药物代谢动力学模型预测氯氮平联合用药的药物相互作用

牟凡, 黄志伟, 程渝, 赵雪, 李华芳, 禹顺英

Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying

表3 氯氮平-氟伏沙明PBPK模型药物代谢动力学参数比较

Tab 3 Comparison of pharmacokinetic parameters of clozapine-fluvoxamine PBPK model

Drug administration	Pharmacokinetic parameter	Combination therapy/monotherapy		No effect boundary
Drug administration	Pharmacokinetic parameter	mean/%	90%CI	No effect boundary
Administration 1	C_max/(ng·mL^-1)	180	111%‒223%	80%‒125%
Administration 1	AUC/(ng·h·mL^-1)	197	105%‒204%
Administration 2	C_max/(ng·mL^-1)	175	110%‒240%
Administration 2	AUC/(ng·h·mL^-1)	189	100%‒277%