长寿蛋白SIRT6在衰老和代谢中作用的研究进展

刘永慧, 唐莉, 梁泰刚, 张健, 冯丽

Research progress in the role of SIRT6 in aging and metabolism

LIU Yonghui, TANG Li, LIANG Taigang, ZHANG Jian, FENG Li

图2 SIRT6催化去酰化的分子机制 Note： NAD+ acts as a cofactor to assist SIRT6 in removing acylation groups from substrate lysine residues, resulting in the generation of NAM, ADP ribose, and the deacetylated product.

Fig 2 Mechanism of SIRT6 catalyzing deacylation