单细胞基因组学比较人诱导多能干细胞来源巨噬细胞与外周血来源巨噬细胞的异质性

张羽桐, 侯国俊, 沈南

Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics

ZHANG Yutong, HOU Guojun, SHEN Nan

表2 IPSDM与PBDM中细胞类型、对应的标志基因和细胞数

Tab 2 Cell types, the corresponding marker genes and cell numbers in IPSDM and PBDM

Cell type Marker gene IPSDM/n(%) PBDM/n(%) Total ‒ 9 745 1 796 Macrophage CD14, CD68, S100A11, and CD163 9 467 (97.15) 1 794 (99.89) HPC-like cell HES1, SOX4, CDK6, RUNX1T1, and MECOM 264 (2.71) 2 (0.11) Dendritic cell ITGAM and ITGAX 14 (0.14) 0 (0)