单细胞基因组学比较人诱导多能干细胞来源巨噬细胞与外周血来源巨噬细胞的异质性

张羽桐, 侯国俊, 沈南

Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics

ZHANG Yutong, HOU Guojun, SHEN Nan

表3 PBDM与IPSDM中的巨噬细胞之间上调与下调变化倍数排名前10的DEG

Tab 3 Top 10 DEGs with up- and down-regulated fold changes between the macrophages from PBDM and IPSDM

Gene Average log2FC pct.1 pct.2 P value Adjusted P value MAP4K3-DT 10.399 0.497 0 8.45×10-305 1.66×10-301 PNRC2 10.246 0.498 0 2.28×10-305 4.50×10-302 TENT2 10.154 0.488 0 8.07×10-297 1.59×10-293 SELENON 9.884 0.402 0 2.94×10-226 5.79×10-223 RAB7B 9.847 0.341 0 2.27×10-181 4.47×10-178 FAAP20 9.780 0.396 0 2.85×10-221 5.61×10-218 RAB29 9.757 0.405 0 1.58×10-228 3.11×10-225 UTP11 9.677 0.370 0 6.19×10-202 1.22×10-198 TMEM35B 9.662 0.377 0 2.08×10-207 4.11×10-204 ELOA 9.568 0.376 0 7.27×10-207 1.43×10-203 EMILIN1 -3.939 0.049 0.278 7.48×10-244 1.47×10-240 CCR5 -2.685 0.147 0.319 3.16×10-102 6.22×10-99 PHLDA3 -2.645 0.160 0.430 7.26×10-208 1.43×10-204 PCM1 -2.429 0.578 0.719 5.15×10-262 1.02×10-258 VAMP3 -2.383 0.424 0.679 7.93×10-295 1.56×10-291 RRM2 -2.362 0.086 0.307 9.29×10-164 1.83×10-160 AGO1 -2.284 0.279 0.432 7.54×10-97 1.49×10-93 ITPKB -2.238 0.166 0.279 1.49×10-51 2.94×10-48 SMC4 -2.161 0.235 0.337 6.41×10-46 1.26×10-42 MAPK14 -2.077 0.372 0.499 1.82×10-102 3.58×10-99