NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性

袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开

Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits

YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai

表1 rs7305526和rs11615756的eQTL分析

Tab 1 eQTL analysis of rs7305526 and rs11615756

SNP Tissue Effect size P value rs7305526 Brain cortex -0.127 0.044 Lung -0.136 <0.001 Tibial nerve 0.178 <0.001 Colon sigmoid -0.061 0.039 Heart atrial appendage -0.155 0.014 Minor salivary gland 0.141 0.033 Thyroid 0.099 0.049 rs11615756 Brain amygdala -0.224 0.008 Brain cortex -0.151 0.028 Esophagus mucosa -0.084 0.031 Thyroid 0.104 0.049 Skeletal muscle 0.061 0.017 Pancreas 0.114 0.020