NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性
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袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开
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Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits
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YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai
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表3 rs7305526各基因型特征
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Tab 3 Characteristics of each genotype of rs7305526
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| Variable | Overall (n=6 026) | AA (n=1 941) | CA (n=2 867) | CC (n=1 077) | P value |
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| Genotype/n(%) | | | | | <0.001 | | AA | 1 941 (32.2) | 1 941 (100.0) | 0 (0) | 0 (0) | | | CA | 2 867 (47.6) | 0 (0) | 2 867 (100.0) | 0 (0) | | | CC | 1 077 (17.9) | 0 (0) | 0 (0) | 1 077 (100.0) | | | NA | 141 (2.3) | 0 (0) | 0 (0) | 0 (0) | | | Gender/n(%) | | | | | 0.175 | | Male | 5 325 (88.4) | 1 699 (87.5) | 2 538 (88.5) | 967 (89.8) | | | Female | 701 (11.6) | 242 (12.5) | 329 (11.5) | 110 (10.2) | | | Smoking status/n(%) | | | | | 0.924 | | Never | 3 926 (65.2) | 1 262 (65.0) | 1 872 (65.3) | 708 (65.7) | | | Ever | 2 100 (34.8) | 679 (35.0) | 995 (34.7) | 369 (34.3) | | | Drinking status/n(%) | | | | | 0.862 | | Never | 3 637 (60.4) | 1 181 (60.8) | 1 722 (60.1) | 650 (60.4) | | | Ever | 2 389 (39.6) | 760 (39.2) | 1 145 (39.9) | 427 (39.6) | | | AHI (events/h)①/n(%) | | | | | <0.001 | | AHI< 5 (Non-OSA) | 764 (12.7) | 212 (10.9) | 360 (12.6) | 173 (16.1) | | | 5 ≤AHI < 15 (Mild-OSA) | 318 (5.3) | 90 (4.6) | 161 (5.6) | 63 (5.9) | | | 15 ≤AHI < 30 (Moderate-OSA) | 1 245 (20.7) | 407 (21.0) | 577 (20.1) | 235 (21.9) | | | ≥30 (Severe-OSA) | 3 692 (61.3) | 1 231 (63.4) | 1 766 (61.6) | 603 (56.1) | | | T2DM status/n(%) | | | | | 0.787 | | No | 5 580 (92.6) | 1 790 (92.2) | 2 658 (92.7) | 999 (92.8) | | | Yes | 446 (7.4) | 151 (7.8) | 209 (7.3) | 78 (7.2) | | | Hypertension status/n(%) | | | | | 0.761 | | No | 5 141 (85.3) | 1 649 (85.0) | 2 452 (85.5) | 925 (85.9) | | | Yes | 885 (14.7) | 292 (15.0) | 415 (14.5) | 152 (14.1) | |
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