NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性
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袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开
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Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits
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YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai
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表4 rs11615756各基因型特征
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Tab 4 Characteristics of each genotype of rs11615756
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| Variable | Overall (n=6 026) | CC (n=3 352) | TC (n=2 236) | TT (n=385) | P value |
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| Genotype/n(%) | | | | | <0.001 | | CC | 3 352 (55.6) | 3 352 (100.0) | 0 (0) | 0 (0) | | | TC | 2 236 (37.1) | 0 (0) | 2 236 (100.0) | 0 (0) | | | TT | 3 85 (6.4) | 0 (0) | 0 (0) | 385 (100.0) | | | NA | 53 (0.9) | 0 (0) | 0 (0) | 0 (0) | | | Gender/n(%) | | | | | 0.027 | | Male | 5 325 (88.4) | 2 965 (88.5) | 1 956 (87.5) | 355 (92.2) | | | Female | 701 (11.6) | 387 (11.5) | 280 (12.5) | 30 (7.8) | | | Smoking status/n(%) | | | | | 0.599 | | Never | 3 926 (65.2) | 2 183 (65.1) | 1 465 (65.5) | 242 (62.9) | | | Ever | 2 100 (34.8) | 1 169 (34.9) | 771 (34.5) | 143 (37.1) | | | Drinking status/n(%) | | | | | 0.513 | | Never | 3 637 (60.4) | 2 004 (59.8) | 1 371 (61.3) | 231 (60.0) | | | Ever | 2 389 (39.6) | 1 348 (40.2) | 865 (38.7) | 154 (40.0) | | | AHI (events/h)①/n(%) | | | | | 0.685 | | AHI< 5 (Non-OSA) | 764 (12.7) | 421 (12.6) | 293 (13.1) | 44 (11.4) | | | 5 ≤AHI < 15 (Mild-OSA) | 318 (5.3) | 184 (5.5) | 109 (4.9) | 22 (5.7) | | | 15 ≤AHI < 30 (Moderate-OSA) | 1 245 (20.7) | 700 (20.9) | 459 (20.6) | 70 (18.2) | | | ≥30 (Severe-OSA) | 3 692 (61.3) | 2 044 (61.0) | 1 371 (61.4) | 249 (64.7) | | | T2DM status/n(%) | | | | | 0.989 | | No | 5 580 (92.6) | 3 104 (92.6) | 2 072 (92.7) | 356 (92.5) | | | Yes | 446 (7.4) | 248 (7.4) | 164 (7.3) | 29 (7.5) | | | Hypertension status/n(%) | | | | | 0.568 | | No | 5 141 (85.3) | 2 863 (85.4) | 1 896 (84.8) | 334 (86.8) | | | Yes | 885 (14.7) | 489 (14.6) | 340 (15.2) | 51 (13.2) | |
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