NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性

袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开

Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits

YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai

表6 rs7305526和rs11615756与OSA临床数量性状的关联

Tab 6 Associations of genetic variants rs7305526 and rs11615756 with clinical quantitative traits of OSA

SNP Allele Trait OR 95%CI P value Lower Upper rs7305526 C>A AHItotal 0.126 0.049 0.326 <0.001 AHIREM 0.189 0.071 0.502 <0.001 AHINREM 0.153 0.057 0.415 <0.001 ODI 0.111 0.040 0.313 <0.001 LT90 0.008 0.001 0.188 0.003 LT80 0.160 0.027 0.964 0.046 LT70 0.436 0.192 0.990 0.047 LSpO2 4.455 2.548 7.784 <0.001 SSS 0.866 0.787 0.954 0.004 WK(TIB) frequency 1.239 1.011 1.517 0.039 WK(TIB) duration 34.022 3.300 350.724 0.003 WK/TIB 1.848 1.136 3.007 0.013 N2 frequency 0.818 0.446 1.500 0.515 N2/TIB 0.482 0.258 0.901 0.022 N3 frequency 0.861 0.501 1.477 0.586 rs11615756 T>C AHItotal 1.352 0.464 3.939 0.581 AHIREM 1.578 0.521 4.783 0.420 AHINREM 0.862 0.280 2.658 0.796 ODI 1.225 0.381 3.939 0.733 LT90 0.032 0.001 1.165 0.061 LT80 0.512 0.067 3.908 0.519 LT70 0.911 0.361 2.301 0.844 LSpO2 0.946 0.501 1.785 0.864 SSS 1.025 0.919 1.143 0.661 WK(TIB) frequency 0.880 0.700 1.107 0.275 WK(TIB) duration 1.690 0.120 23.712 0.697 WK/TIB 1.204 0.693 2.091 0.510 N2 frequency 0.364 0.184 0.720 0.004 N2/TIB 0.737 0.355 1.533 0.414 N3 frequency 0.440 0.240 0.807 0.008