NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性

袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开

Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits

YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai

表7 男性与女性rs7305526和rs11615756与OSA临床数量性状的关联

Tab 7 Associations of genetic variants rs7305526 and rs11615756 with clinical quantitative traits of OSA in male and female groups

Gender SNP Allele Trait OR 95%CI P value Lower Upper Male rs7305526 C>A AHItotal 0.103 0.037 0.285 <0.001 AHIREM 0.189 0.066 0.535 0.002 AHINREM 0.111 0.038 0.322 <0.001 ODI 0.093 0.031 0.281 <0.001 LT90 0.004 0.001 0.116 0.001 LT80 0.177 0.029 1.087 0.061 LT70 0.540 0.252 1.154 0.112 LSpO2 4.782 2.821 8.108 <0.001 SSS 0.865 0.781 0.958 0.006 WK (TIB) frequency 1.215 0.979 1.508 0.078 WK (TIB) duration 36.696 3.154 426.991 0.004 WK/TIB 2.002 1.208 3.318 0.007 N2 frequency 0.781 0.412 1.482 0.450 N2/TIB 0.129 0.006 2.867 0.195 N3 frequency 2.881 0.268 30.958 0.382 rs11615756 T>C AHItotal 1.251 0.398 3.929 <0.001 AHIREM 1.246 0.385 4.039 0.002 AHINREM 0.890 0.268 2.962 <0.001 ODI 1.049 0.303 3.638 <0.001 LT90 0.049 0.001 2.051 0.001 LT80 0.369 0.047 2.868 0.061 LT70 0.748 0.317 1.764 0.112 LSpO2 1.159 0.638 2.105 <0.001 SSS 1.020 0.909 1.144 0.006 WK (TIB) frequency 0.862 0.676 1.100 0.078 WK (TIB) duration 4.212 0.264 67.122 0.004 WK/TIB 1.430 0.808 2.531 0.007 N2 frequency 0.356 0.174 0.726 0.450 N2/TIB 0.823 0.025 27.424 0.195 N3 frequency 0.197 0.014 2.876 0.382 Female rs7305526 C>A AHItotal 0.726 0.060 8.786 0.801 AHIREM 0.371 0.025 5.499 0.471 AHINREM 1.586 0.106 23.735 0.738 ODI 0.761 0.045 12.926 0.850 LT90 0.238 0.002 5 373.921 0.779 LT80 0.128 0.001 195.286 0.581 LT70 0.163 0.006 4.516 0.283 LSpO2 1.137 0.266 4.854 0.862 SSS 0.846 0.635 1.127 0.253 WK (TIB) frequency 1.352 0.766 2.384 0.298 WK (TIB) duration 26.286 0.017 41 622.230 0.384 WK/TIB 1.857 0.394 8.760 0.434 N2 frequency 1.020 0.152 6.841 0.984 N2/TIB 0.002 0.001 2.374 0.078 N3 frequency 11.913 0.017 8 142.930 0.456 rs11615756 T>C AHItotal 3.274 0.174 61.738 0.428 AHIREM 19.344 0.799 468.319 0.068 AHINREM 0.808 0.034 19.383 0.895 ODI 5.700 0.202 161.096 0.307 LT90 0.004 0.001 716.665 0.375 LT80 14.017 0.003 65 377.371 0.539 LT70 20.663 0.444 960.811 0.122 LSpO2 0.397 0.073 2.162 0.285 SSS 1.092 0.781 1.529 0.606 WK (TIB) frequency 1.047 0.537 2.040 0.893 WK (TIB) duration 0.002 0.001 3.107 0.088 WK/TIB 0.303 0.049 1.871 0.198 N2 frequency 0.546 0.057 5.229 0.599 N2/TIB 0.093 0.001 2 235.485 0.644 N3 frequency 0.096 0.001 201.306 0.547