NOS1基因变异与失眠、睡眠时长以及阻塞性睡眠呼吸暂停临床数量性状的相关性
袁灏琳, 李念念, 胡珺晖, 沈锦虹, 高振飞, 关建, 刘峰, 殷善开

Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits
YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai
表8 非OSA组，以及轻度、中度和重度OSA组rs7305526和rs11615756与OSA临床数量性状的关联
Tab 8 Associations between genetic variants rs7305526 and rs11615756 with clinical quantitative traits of OSA in non-OSA， mild-OSA， moderate-OSA and severe-OSA groups
SNPTraitNon-OSA (n=764)Mild-OSA (n=318)Moderate-OSA (n=1 245)Severe-OSA (n=3 692)

P

value

OR

(95%CI)

P

value

OR

(95%CI)

P

value

OR

(95%CI)

P value

OR

(95%CI)

rs7305526AHItotal0.530

0.955

(0.826‒1.104)

0.290

0.818

(0.563‒1.188)

0.619

1.090

(0.777‒1.528)

0.206

0.593

(0.264‒1.334)

AHIREM0.763

1.176

(0.410‒3.380)

0.965

1.070

(0.054‒21.232)

0.890

0.894

(0.182‒4.383)

0.577

0.749

(0.271‒2.070)

AHINREM0.464

1.461

(0.529‒4.0332)

0.143

4.276

(0.611‒29.910)

0.846

1.076

(0.517‒2.239)

0.206

0.538

(0.205‒1.408)

ODI0.821

0.847

(0.199‒3.602)

0.562

1.330

(0.505‒3.501)

0.124

0.516

(0.222‒1.200)

0.464

0.684

(0.247‒1.892)

LT900.633

0.536

(0.041‒6.958)

0.036

23.117

(1.232‒433.679)

0.632

1.864

(0.146‒23.881)

0.122

0.032

(0.001‒2.517)

LT800.982

0.999

(0.907‒1.100)

0.097

1.397

(0.941‒2.074)

0.678

0.878

(0.475‒1.624)

0.392

0.290

(0.017‒4.948)

LT700.278

0.998

(0.993‒1.002)

0.613

0.990

(0.951‒1.030)

0.331

1.064

(0.939‒1.205)

0.179

0.424

(0.121‒1.481)

LSpO20.019

2.039

(1.124‒3.699)

0.958

1.028

(0.372‒2.841)

0.022

2.280

(1.129‒4.605)

0.008

2.217

(1.226‒4.011)

SSS0.421

0.888

(0.666‒1.186)

0.333

1.193

(0.834‒1.706)

0.995

1.001

(0.817‒1.226)

0.153

0.923

(0.826‒1.030)

WK (TIB) frequency0.215

1.498

(0.791‒2.838)

0.016

0.369

(0.163‒0.832)

0.130

1.432

(0.900‒2.281)

0.244

1.158

(0.905‒1.4811)

WK (TIB) duration0.119

406.376

(0.213‒775 370.391)

0.606

0.060

(0.001‒2674.448)

0.046

269.283

(1.095‒66 255.145)

0.230

5.352

(0.345‒83.043)

WK/TIB0.097

3.846

(0.784‒18.871)

0.714

0.661

(0.072‒6.081)

0.142

2.251

(0.763‒6.641)

0.240

1.411

(0.794‒2.508)

N2 frequency0.788

0.857

(0.277‒2.650 6)

0.432

0.454

(0.063‒3.278)

0.921

0.942

(0.289‒3.071)

0.892

0.942

(0.398‒2.230)

N2/TIB0.214

0.009

(0.001‒15.720)

0.035

0.002

(0.001‒0.405)

0.678

0.272

(0.001‒128.335)

0.695

0.462

(0.010‒21.825)

N3 frequency0.295

0.045

(0.001‒14.873)

0.021

10 267.538

(3.963‒26 600 123.192)

0.528

4.297

(0.046‒400.757)

0.648

2.015

(0.099‒40.930)

rs11615756AHItotal0.777

0.976

(0.823‒1.157)

0.875

0.968

(0.639‒1.464)

0.626

1.104

(0.742‒1.642)

0.626

0.801

(0.328‒1.957)

AHIREM0.027

0.251

(0.074‒0.856)

0.791

1.551

(0.060‒40.217)

0.085

5.121

(0.800‒32.802)

0.750

1.202

(0.389‒3.711)

AHINREM0.029

0.270

(0.083‒0.875)

0.504

0.500

(0.065‒3.838)

0.392

1.457

(0.616‒3.448)

0.377

0.620

(0.214‒1.793)

ODI0.123

0.266

(0.050‒1.429)

0.846

1.112

(0.381‒3.249)

0.840

1.108

(0.411‒2.98)

0.994

1.004

(0.327‒3.080)

LT900.511

2.705

(0.139‒52.722)

0.076

0.053

(0.002‒1.364)

0.324

4.571

(0.222‒93.989)

0.006

0.002

(0.001‒0.148)

LT800.407

0.952

(0.848‒1.069)

0.757

1.074

(0.682‒1.690)

0.077

1.885

(0.933‒3.807)

0.290

0.184

(0.008‒4.251)

LT700.314

0.997

(0.992‒1.003)

0.565

0.987

(0.943‒1.033)

0.035

1.166

(1.011‒1.344)

0.857

0.881

(0.221‒3.504)

LSpO20.951

1.022

(0.511‒2.046)

0.314

1.780

(0.577‒5.489)

0.480

0.743

(0.326‒1.696)

0.357

1.362

(0.706‒2.627)

SSS0.697

1.070

(0.762‒1.501)

0.019

0.626

(0.423‒0.926)

0.949

0.992

(0.782‒1.259)

0.435

1.050

(0.929‒1.186)

WK (TIB) frequency0.238

0.636

(0.300‒1.349)

0.835

1.101

(0.444‒2.731)

0.917

0.971

(0.561‒1.682)

0.470

0.905

(0.689‒1.188)

WK (TIB) duration0.397

46.583

(0.006‒338 729.248)

0.531

43.721

(0.001‒6 081 353.502)

0.772

0.381

(0.001‒256.719)

0.879

1.266

(0.061‒26.225)

WK/TIB0.456

2.041

(0.313‒13.327)

0.661

1.729

(0.148‒20.150)

0.845

0.881

(0.245‒3.167)

0.517

1.234

(0.653‒2.331)

N2 frequency0.135

0.366

(0.098‒1.370)

0.934

0.911

(0.099‒8.373)

0.918

0.930

(0.234‒3.703)

0.005

0.261

(0.101‒0.671)

N2/TIB0.091

2 007.782

(0.296‒13 627 828.272)

0.832

3.998

(0.001‒1 516 906.783)

0.407

0.046

(0.001‒66.068)

0.498

0.228

(0.003‒16.421)

N3 frequency0.979

1.094

(0.001‒976.421)

0.665

0.145

(0.001‒929.697)

0.778

0.464

(0.002‒96.210)

0.173

0.098

(0.004‒2.775)