GPR87通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

刘晨茜, 韩林, 杨轶, 周韩, 刘亚云, 盛德乔

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

图3 GPR87 mRNA和蛋白在不同NSCLC细胞模型中的表达分析 Note： Relative mRNA expression of GPR87 in SK-MES-1 and A549 cells, as predicted by CCLE (A), analyzed by RT-qPCR analysis (B), and relative protein expression of GPR87 by Western blotting analysis (C). Relative mRNA expression of GPR87 by RT-qPCR analysis (D) and relative protein expression of GPR87 by Western blotting analysis (E) in SK-MES-1 cells treated with siRNA-GPR87. GPR87 protein expression in A549 cells treated with pCMV-GPR87-his by Western blotting analysis (F). Error bars represent the x±s. ①P=0.037, ②P=0.008, compared with SK-MES-1. ③P<0.001, compared with SK-MES-1. ④P=0.008, ⑤P=0.005, ⑥P=0.006, compared with control group. ⑦P<0.001, compared with control group.

Fig 3 Analysis of GPR87 mRNA and protein expression in NSCLC cell models