GPR87通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

刘晨茜, 韩林, 杨轶, 周韩, 刘亚云, 盛德乔

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

图4 Transwell检测 GPR87 对NSCLC细胞迁移和侵袭的影响 Note： Representative images (×200) and quantification of migrated (A) and invaded (B) cells, analyzed by using the Transwell matrix penetration assay in SK-MES-1 and A549 cells treated with siRNA-GPR87. Representative images (×200) and quantification of migrated (C) and invaded (D) cells, analyzed by Transwell matrix penetration assay in SK-MES-1 and A549 cells treated with pCMV-GPR87-his. Error bars represent the x±s. ①P<0.001, compared with the NC group. ②P=0.008, compared with the Vector group. ③P<0.001, compared with the Vector group.

Fig 4 Effect of GPR87 on migration and invasion in NSCLC cell lines by the Transwell assay