GPR87通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

刘晨茜, 韩林, 杨轶, 周韩, 刘亚云, 盛德乔

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

图6 GRP87 对NSCLC细胞EMT的影响 Note： The mRNA expression (A) of E-cadherin, N-cadherin, vimentin, snail, and twist, and the protein expression (B) of E-cadherin and vimentin did not change in SK-MES-1 cells treated with siRNA-GPR87. The mRNA expression of E-cadherin, N-cadherin, and vimentin (C), and the protein expression of E-cadherin and vimentin (D) did not change in A549 cells treated with pCMV-GPR87-his. Error bars represent the x±s. ①P<0.001, compared with the NC group. ②P=0.008, compared with the Vector group.

Fig 6 Effect of GPR87 on EMT in NSCLC cell lines