<i>GPR87</i>通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

GPR87通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

刘晨茜, 韩林, 杨轶, 周韩, 刘亚云, 盛德乔

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

图7 GPR87 对NSCLC细胞RHO/ROCK通路的影响
Note： A. The mRNA expression of RHOA, RHOC and ROCK1 was decreased in SK-MES-1 cells treated with siRNA-GPR87. B. The protein expression of RHOA and ROCK1 in SK-MES-1 and A549 cells treated with siRNA-GPR87 was decreased, as detected by Western blotting. C. The mRNA expression of RHOA, RHOC and ROCK1 in A549 cells treated with pCMV-GPR87-his was increased. D. The protein expression of RHOA and ROCK1 was increased in SK-MES-1 and A549 cells treated with pCMV-GPR87-his, as detected by Western blotting. Error bars represent the x±s.^①P=0.008, ^②P=0.035, ^③P=0.041, ^④P=0.005, ^⑤P<0.001, ^⑥P=0.019,^⑦P=0.026, compared with the NC group.^⑧P=0.003,^⑨P=0.002, ^⑩P=0.007, ¹¹P<0.001,¹²P=0.008, compared with the Vector group.

Fig 7 Effect of GPR87 on the RHO/ROCK signaling pathway in NSCLC cell lines