GPR87通过激活RHO/ROCK通路促进非小细胞肺癌的侵袭和迁移

刘晨茜, 韩林, 杨轶, 周韩, 刘亚云, 盛德乔

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

表5 GPR87与NSCLC患者的临床相关性分析

Tab 5 The relevance of GPR87 expression to clinicopathological characteristics in NSCLC patients

Factor Case/n Expression of GPR87/n χ2 P value High Low Subgroup 1.524 0.217 LUAD 48 28 20 LUSC 32 23 9 Age/year 0.197 0.657 ≥65 36 22 14 <65 44 29 15 Gender 0.442 0.506 Male 48 32 16 Female 32 19 13 Smoking 0.548 0.459 Yes/ever 43 29 14 No 37 22 15 Differentiation 1.847 0.174 Good 11 5 6 Middle/poor 69 46 23 Stage 10.498 0.001 Ⅰ/Ⅱ 65 36 29 Ⅲ/Ⅳ 15 15 0 Lymphatic metastasis 5.485 0.019 No 50 27 23 Yes 30 24 6