牙周致病菌编码的Tannerpin-M对粒细胞释放的丝氨酸蛋白酶的抑制作用

潘子豪, 许佳伟, 周爱武

Inhibition of Tannerpin-M encoded by periodontal pathogens on serine proteases released by granulocytes

PAN Zihao, XU Jiawei, ZHOU Aiwu

表1 Tennerpin-M晶体结构信息

Tab 1 Crystallographic statistics of Tannerpin-M structure

Item Data collection Beamline SSRF 18U Space group P1211 Cell dimension a, b, c /Å 46.07, 112.52, 73.62 α, β, γ /(°) 90, 98.81, 90 Wavelength/Å 0.98 Resolution/Å 45.53‒2.4 (2.486‒2.4) Total No. of observation 54 039 (5 190) Total No. unique 27 693 (2 698) Rmerge/% 0.066 (0.248) I/σI 8.81 (3.22) Completeness/% 95.35 (93.71) Multiplicity 8.81 (3.22) R-meas 0.094 (0.351) CC1/2 0.993 (0.856) Refinement Reflections used in refinement 27 676 (2 697) Reflections used for R-free 1 369 (140) Number of non-hydrogen atoms 5 745 Macromolecule 5 714 Ligand 6 Solvent 25 Protein residue 729 R-work 0.221 (0.275) R-free 0.273 (0.344) B-factor/Å2 24.78 RMSD bond length/Å 0.002 RMSD bond angle/(°) 0.52 Ramachandran favored/allowed/outlier/% 97.36/2.36/0.28