基于单细胞测序技术解析冠状动脉粥样硬化患者平滑肌细胞的细胞间通信及关键基因

司春婴, 王建茹, 李晓辉, 王永霞, 关怀敏

Study on intercellular communication and key genes of smooth muscle cells in human coronary atherosclerosis based on single cell sequencing technology

SI Chunying, WANG Jianru, LI Xiaohui, WANG Yongxia, GUAN Huaimin

表2 关键基因介导的细胞间信号通路

Tab 2 Hub genes-mediated cell signaling pathway

Source Target Ligand Receptor Probability P value Interaction name Pathway Annotation Evidence (PMID) Chondrocyte Endothelial cell CCL2 ACKR1 0.053 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Macrophage Endothelial cell CCL2 ACKR1 0.042 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Monocyte Endothelial cell CCL2 ACKR1 0.047 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Neuron Endothelial cell CCL2 ACKR1 0.060 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Smooth muscle cell Endothelial cell CCL2 ACKR1 0.244 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Tissue stem cell Endothelial cell CCL2 ACKR1 0.021 0.000 CCL2-ACKR1 CCL Secreted signaling 26740381 Macrophage Macrophage C3 ITGAM_ITGB2 0.004 0.000 C3-(ITGAM+ITGB2) Complement Secreted signaling 16234578 Smooth muscle cell Macrophage C3 ITGAM_ITGB2 0.040 0.000 C3-(ITGAM+ITGB2) Complement Secreted signaling 16234578 Macrophage Monocyte C3 ITGAM_ITGB2 0.005 0.000 C3-(ITGAM+ITGB2) Complement Secreted signaling 16234578 Smooth muscle cell Monocyte C3 ITGAM_ITGB2 0.046 0.000 C3-(ITGAM+ITGB2) Complement Secreted signaling 16234578 Macrophage Macrophage C3 ITGAX_ITGB2 0.004 0.000 C3-(ITGAX+ITGB2) Complement Secreted signaling 16234578 Smooth muscle cell Macrophage C3 ITGAX_ITGB2 0.040 0.000 C3-(ITGAX+ITGB2) Complement Secreted signaling 16234578