空腹血糖升高与认知功能恶化的代谢关联研究

吴丽蓉, 陈瑞华, 晁筱雯, 郭雨槐, 孙涛, 李梦慈, 陈天璐

Study of metabolic association between elevated fasting blood glucose and cognitive deterioration

WU Lirong, CHEN Ruihua, CHAO Xiaowen, GUO Yuhuai, SUN Tao, LI Mengci, CHEN Tianlu

表5 无认知功能恶化人群和有认知功能恶化人群的基线数据差异代谢指标（全人群）

Tab 5 Differential metabolic indicators between the individuals without and with cognitive deterioration at baseline （all data）

Indicator P value Trend VIP value All data Sphingomyelins 0.041 ↓ 1.66 Phospholipids to total lipids ratio in medium HDL 0.011 ↑ 1.93 Cholesterol to total lipids ratio in medium HDL 0.037 ↓ 1.31 Phospholipids to total lipids ratio in IDL 0.034 ↑ 2.71 Phospholipids to total lipids ratio in very small VLDL 0.009 ↑ 2.39 Normal FBG group Cholesteryl esters to total lipids ratio in large HDL 0.026 ↓ 1.13 Phospholipids to total lipids ratio in medium HDL 0.020 ↑ 2.23 Cholesterol to total lipids ratio in medium HDL 0.045 ↓ 1.78 Phospholipids to total lipids ratio in very small VLDL 0.049 ↑ 2.51 High FBG group Valine 0.023 ↑ 1.02 Histidine 0.014 ↑ 1.38 Phospholipids to total lipids ratio in medium HDL 0.042 ↑ 1.08 Free cholesterol to total lipids ratio in small HDL 0.017 ↓ 1.21 Cholesteryl esters to total lipids ratio in IDL 0.044 ↓ 1.53 Phospholipids to total lipids ratio in IDL 0.010 ↑ 2.16 Phospholipids to total lipids ratio in very large VLDL 0.049 ↑ 1.91 Free cholesterol to total lipids ratio in very large VLDL 0.016 ↑ 1.92 Phospholipids to total lipids ratio in very small VLDL 0.033 ↑ 1.75