空腹血糖升高与认知功能恶化的代谢关联研究

吴丽蓉, 陈瑞华, 晁筱雯, 郭雨槐, 孙涛, 李梦慈, 陈天璐

Study of metabolic association between elevated fasting blood glucose and cognitive deterioration

WU Lirong, CHEN Ruihua, CHAO Xiaowen, GUO Yuhuai, SUN Tao, LI Mengci, CHEN Tianlu

表 6 认知功能恶化人群在认知恶化发生前后的显著差异代谢指标

Tab 6 Differential metabolic indicators between the individuals with cognitive deterioration before and after cognitive deterioration

Indicator P value Trend VIP value All data Leucine 0.001 ↑ 1.03 Phenylalanine <0.001 ↑ 1.63 Albumin 0.008 ↑ 1.24 Total lipids in very large HDL 0.046 ↓ 2.06 Free cholesterol in very large HDL 0.027 ↓ 2.48 Phospholipids in very large HDL 0.030 ↓ 2.14 Cholesterol to total lipids ratio in very large HDL 0.029 ↑ 2.08 Cholesteryl esters to total lipids ratio in very large HDL 0.006 ↑ 2.40 Phospholipids to total lipids ratio in very large HDL 0.017 ↓ 2.37 Free cholesterol to total lipids ratio in large HDL 0.014 ↓ 1.73 Concentration of small HDL particles 0.002 ↑ 2.78 Total lipids in small HDL 0.007 ↑ 2.38 Total cholesterol in small HDL 0.004 ↑ 2.83 Free cholesterol in small HDL 0.027 ↑ 1.91 Cholesterol esters in small HDL 0.002 ↑ 3.04 Phospholipids in small HDL 0.022 ↑ 2.05 Cholesterol to total lipids ratio in small LDL 0.002 ↑ 2.28 Cholesteryl esters to total lipids ratio in small LDL 0.004 ↑ 1.16 Phospholipids to total lipids ratio in small LDL 0.001 ↓ 1.85 Cholesterol to total lipids ratio in very large VLDL 0.045 ↑ 1.22 Cholesteryl esters to total lipids ratio in very large VLDL 0.038 ↑ 1.55 Normal FBG group Phenylalanine <0.001 ↑ 1.64 Leucine 0.005 ↑ 1.01 Albumin 0.030 ↑ 1.35 Cholesterol to total lipids ratio in very large HDL 0.043 ↑ 2.22 Cholesteryl esters to total lipids ratio in very large HDL 0.014 ↑ 2.57 Phospholipids to total lipids ratio in very large HDL 0.044 ↓ 2.14 Free cholesterol in very large HDL 0.048 ↓ 2.32 Free cholesterol to total lipids ratio in large HDL 0.022 ↓ 1.50 Concentration of small HDL particles 0.005 ↑ 2.95 Total lipids in small HDL 0.011 ↑ 2.60 Free cholesterol in small HDL 0.030 ↑ 2.19 Total cholesterol in small HDL 0.008 ↑ 2.97 Cholesterol esters in small HDL 0.006 ↑ 3.14 Phospholipids in small HDL 0.029 ↑ 2.29 Cholesterol to total lipids ratio in small LDL 0.003 ↑ 2.70 Cholesteryl esters to total lipids ratio in small LDL 0.003 ↑ 1.71 Phospholipids to total lipids ratio in small LDL 0.002 ↓ 2.26 Cholesterol to total lipids ratio in very large VLDL 0.042 ↑ 1.40 Cholesteryl esters to total lipids ratio in very large VLDL 0.043 ↑ 1.64 High FBG group Concentration of medium LDL particles 0.031 ↑ 1.93 Total lipids in medium LDL 0.030 ↑ 2.15 Cholesterol esters in medium LDL 0.033 ↑ 2.15 Phospholipids in medium LDL 0.023 ↑ 2.18 Phospholipids to total lipids ratio in IDL 0.037 ↓ 1.94 Total lipids in small LDL 0.036 ↑ 1.96 Cholesterol esters in small LDL 0.049 ↑ 1.95 Phospholipids in small LDL 0.043 ↑ 1.82