氧化三甲胺损害肥厚型心肌病小鼠心功能的机制研究

靳步, 陈汉章, 徐浒东, 陈婉玉, 袁颖, 赵婷婷, 黄晓蕾, 何佳璐, 于红

Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy

JIN Bu, CHEN Hanzhang, XU Hudong, CHEN Wanyu, YUAN Ying, ZHAO Tingting, HUANG Xiaolei, HE Jialu, YU Hong

图3 TMAO和IMC对各组小鼠心肌细胞排列规整度和心肌组织纤维化比例的影响 Note： A. HE staining of mouse myocardium tissue in WT group, WT+TMAO group, HCM-1 group and HCM+TMAO group (×20). The blue arrows indicate disordered arrangement of cardiomyocytes. B. Masson staining of mouse myocardium tissue in WT group, WT+TMAO group, HCM-1 group and HCM+TMAO group (×20). Red represents the myocardium tissue and blue represents fibrosis of the myocardium tissue. C. HE staining and Masson staining of mouse myocardium tissue in HCM-2 group and HCM+IMC group (×20).

Fig 3 Effects of TMAO and IMC on the regularity of myocardial cell arrangement and the proportion of myocardial fibrosis in each group of mice