氧化三甲胺损害肥厚型心肌病小鼠心功能的机制研究 |
靳步, 陈汉章, 徐浒东, 陈婉玉, 袁颖, 赵婷婷, 黄晓蕾, 何佳璐, 于红 |
Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy |
JIN Bu, CHEN Hanzhang, XU Hudong, CHEN Wanyu, YUAN Ying, ZHAO Tingting, HUANG Xiaolei, HE Jialu, YU Hong |
图3 TMAO和IMC对各组小鼠心肌细胞排列规整度和心肌组织纤维化比例的影响 Note: A. HE staining of mouse myocardium tissue in WT group, WT+TMAO group, HCM-1 group and HCM+TMAO group (×20). The blue arrows indicate disordered arrangement of cardiomyocytes. B. Masson staining of mouse myocardium tissue in WT group, WT+TMAO group, HCM-1 group and HCM+TMAO group (×20). Red represents the myocardium tissue and blue represents fibrosis of the myocardium tissue. C. HE staining and Masson staining of mouse myocardium tissue in HCM-2 group and HCM+IMC group (×20). |
Fig 3 Effects of TMAO and IMC on the regularity of myocardial cell arrangement and the proportion of myocardial fibrosis in each group of mice |
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