沙蟾毒精抗癌活性及相关机制的研究进展

白雯会, 沈淑坤, 吴英理

Research progress in the anti-cancer activity and related mechanisms of arenobufagin

BAI Wenhui, SHEN Shukun, WU Yingli

表2 由ARE诱导的细胞凋亡和自噬相关的蛋白

Tab 2 Proteins related to apoptosis and autophagy induced by ARE

Type of tumor Type of cell Up-regulation Down-regulation Pancreatic cancer, lung cancer, breast cancer, esophageal squamous cell carcinoma, osteosarcoma[6, 11, 16] BxPC-3, SW 1900, A549, NCI-H460, MCF 7, Eca-109 Cleaved CASPASE 9 Pancreatic cancer, lung cancer[11, 16] BxPC-3, SW 1900, A549, NCI-H460 Cleaved CASPASE 3 Pancreatic cancer, lung cancer, liver cancer, breast cancer[6, 11] BxPC-3, SW 1900, A549, NCI-H460, HepG2/ADM, MCF 7 Cleaved PARP Esophageal squamous cell carcinoma[8] Eca-109 Cleaved CASPASE 8 Breast cancer[17] MCF 7, MDA-MB-468 NOXA Breast cancer, esophageal squamous cell carcinoma, pancreatic cancer[5, 8, 15-16] MCF 7, MDA-MB-468, Eca-109, SW 1990, BxPC-3 P53 Liver cancer, breast cancer, lung cancer, acute leukemia[6, 13, 15, 18] HepG2/ADM, MCF 7, A549, Jurkat, MV-4-11, PC-9 BAX Breast cancer[15] MCF 7 P-JNK Acute leukemia[18] Jurkat, MV-4-11 AIF Liver cancer[6] HepG2/ADM LC3Ⅱ Breast cancer[13] HELA ROS Pancreatic cancer[5] SW 1990, BxPC-3 SMAD3 Pancreatic cancer, breast cancer, lung cancer[11, 15, 19-20] Panc-1, AsPC-1, PC-9 P-ERK Pancreatic cancer, breast cancer[5, 6, 11, 21] Panc-1, AsPC-1 P-AKT Breast cancer[16] MCF 7, MDA-MB-48 MCL-1 Lung cancer[19] PC-9 P-MEK Liver cancer, lung cancer[13, 19] HepG2/ADM, A549, PC-9 BCL-2 Pancreatic cancer[5-6] SW 1990, BxPC-3 PI3K Lung cancer[6, 19] PC-9 C-RAF Pancreatic cancer[5-6] SW 1990, BxPC-3 mTOR Liver cancer[14] HepG2 STAT3 Acute leukemia[18] Jurkat, MV-4-11 XIAP Liver cancer[6] HepG2/ADM LC3Ⅰ Lung cancer[13] A549 SOD Lung cancer[20] A549 GSH Pancreatic cancer[5] SW 1990, BxPC-3 AMPK Pancreatic cancer[5] SW 1990, BxPC-3 P62