3种灵长类动物SAGE1与INTS3相互作用保守性的验证

李晓畅, 李明月, 雷鸣, 武健

Conservation of protein interaction between SAGE1 and INTS3 identified in 3 different types of primates

LI Xiaochang, LI Mingyue, LEI Ming, WU Jian

图4 INTS3CTD-SAGE1CTD 结构预测与相互作用界面分析、INTS3与人类突变体SAGE1免疫共沉淀实验 Note： A. The Human INTS3CTD-INTS6CTD structure published on PDB (id: 7BV7) and its interaction interface. H-bond is marked by black dash line. B. The Human INTS3CTD-SAGE1CTD model created by molecular docking and its interaction interface. C. Immunoprecipitation of full-length INTS3 and full-length SAGE1 mutant in Human. D. The Rhesus INTS3CTD-SAGE1CTD model created by molecular docking and its interaction interface. E. The Marmoset INTS3CTD-SAGE1CTD model created by molecular docking and its interaction interface. F. The Lemur INTS3CTD-SAGE1CTD model created by molecular docking and its interaction interface.

Fig 4 Structure prediction and interaction interface analysis of INTS3CTD-SAGE1CTD, and co-immunoprecipitation experiment of INTS3 with human mutant SAGE1