巨噬细胞M1/M2型极化在不同肝病中的作用研究进展

牛媛媛, 汪龙德, 胥文娟, 李正菊, 张瑞婷, 吴毓谦

Research progress in the role of M1/M2 polarization of macrophages in different liver diseases

NIU Yuanyuan, WANG Longde, XU Wenjuan, LI Zhengju, ZHANG Ruiting, WU Yuqian

图1 巨噬细胞M1/M2型极化参与不同类型肝脏疾病的作用机制 Note： NASH—non-alcoholic steatohepatitis; MCP-1—monocyte chemoattractant protein-1; AMPK—AMP-activated protein kinase; PKB—protein kinase B, also known as AKT; PGE2—prostaglandin E2; EP4—prostaglandin E2 receptor 4; mTOR—mammalian target of rapamycin; NPC1—niemann-pick C1; FGL2—fibrinogen-like protein 2; HSP90—heat shock protein 90; DHFR—dihydrofolate reductase; mtROS—mitochondrial reactive oxygen species; FoxO1—forkhead box protein O1; CCR4—C-C chemokine receptor 4; SLAMF6—signaling lymphocytic activation molecule family member 6; TSPO—translocator protein; YAP—Yes-associated protein; TSG-6—tumor necrosis factor alpha-stimulated gene/inducible protein 6; SIRT1—silent information regulator 1; MMP9—matrix metalloproteinase 9; IGF-1—insulin-like growth factor 1.

Fig 1 Mechanism of M1/M2 polarization of macrophages involved in different types of liver diseases