多能蛋白聚糖在恶性肿瘤中的表达及生物学作用的研究进展

刘林楠, 冯莉, 王龙, 刘嘉寅, 范志松

Research progress in the expression of versican in malignant tumors and its biological roles

LIU Linnan, FENG Li, WANG Long, LIU Jiayin, FAN Zhisong

图1 Versican促肿瘤发展的机制 Note： EGFR—epithelial growth factor receptor; PI3K/AKT—phosphatidylinositol 3-kinase/protein kinase B; HA—hyaluronic acid; HAPLN1—hyaluronan and proteoglycan link protein 1; BAD—BCL-2-associated agonist of cell death; TGF-β—transforming growth factor-β; CAF—cancer-associated fibroblast; NF-κB—nuclear factor κB; TAM—tumor-associated macrophage; EMT—epithelial-mesenchymal transition; VEGF—vascular endothelial growth factor; FN—fibronectin; PD-1—programmed death-1; CTLA-4—cytotoxic T lymphocyte-associated antigen-4.

Fig 1 Mechanism of versican promoting tumor development