多能蛋白聚糖在恶性肿瘤中的表达及生物学作用的研究进展 |
刘林楠, 冯莉, 王龙, 刘嘉寅, 范志松 |
Research progress in the expression of versican in malignant tumors and its biological roles |
LIU Linnan, FENG Li, WANG Long, LIU Jiayin, FAN Zhisong |
图1 Versican促肿瘤发展的机制 Note: EGFR—epithelial growth factor receptor; PI3K/AKT—phosphatidylinositol 3-kinase/protein kinase B; HA—hyaluronic acid; HAPLN1—hyaluronan and proteoglycan link protein 1; BAD—BCL-2-associated agonist of cell death; TGF-β—transforming growth factor-β; CAF—cancer-associated fibroblast; NF-κB—nuclear factor κB; TAM—tumor-associated macrophage; EMT—epithelial-mesenchymal transition; VEGF—vascular endothelial growth factor; FN—fibronectin; PD-1—programmed death-1; CTLA-4—cytotoxic T lymphocyte-associated antigen-4. |
Fig 1 Mechanism of versican promoting tumor development |
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