SAE1与SAE2蛋白相互作用肽抑制剂的多种体外筛选体系的构建与评价

胡晨阳, 陆绍永, 杨秀岩

Establishment and evaluation of various in vitro screening systems for peptide inhibitors targeting SAE1 and SAE2 interaction

HU Chenyang, LU Shaoyong, YANG Xiuyan

图1 ITC筛选体系的建立 Note： A. ITC experiments for the binding of SAE1 to SAE2. B. ITC experiments for the binding of PEPT7 to SAE2. C. ITC experiments for the binding of PEPT2 to SAE2. 1 cal=4.184 J. N—the number of sites per SAE2; K—the binding constant; ΔH—heat change; ΔS—entropy change.

Fig 1 Establishment of ITC screening system