SAE1与SAE2蛋白相互作用肽抑制剂的多种体外筛选体系的构建与评价

胡晨阳, 陆绍永, 杨秀岩

Establishment and evaluation of various in vitro screening systems for peptide inhibitors targeting SAE1 and SAE2 interaction

HU Chenyang, LU Shaoyong, YANG Xiuyan

图3 SPR筛选体系的建立 Note： A. SPR pH scouting results for SAE2 immobilization. B. SPR sensorgrams of SAE1 binding to immobilized SAE2. C. Affinities of YP3 peptides for SAE2 determined by SPR. D. Affinity of YP3D for SAE2 determined by SPR equilibrium analysis.

Fig 3 Establishment of SPR screening system