谷氨酸通路基因多态性交互作用与快感缺失的关联研究

黄欣欣, 刘超, 吕钦谕, 胡国芹, 鲍晨曦, 张瑶, 易正辉

Relationship between polymorphic interaction of glutamate pathway genes and anhedonia

HUANG Xinxin, LIU Chao, LÜ Qinyu, HU Guoqin, BAO Chenxi, ZHANG Yao, YI Zhenghui

表1 3组被试的一般人口学资料、临床特征及快感缺失水平的比较

Tab 1 Comparison of general demographic data， clinical characteristics and anhedonia levels among the three groups of participants

Item	SZ group (n=279)	MDD group (n=236)	HC group (n=236)	χ²/Z/F value	P value
Gender/n(%)				4.757	0.093
Male	146 (52.3)	104 (44.1)	125 (53.0)
Female	133 (47.7)	132 (55.9)	111 (47.0)
Age/year	24.5 (19.0, 31.0)^①,④	27.0 (22.0, 33.0)^②	32.0 (24.0, 57.3)	76.941	0.000
Years of education/year	12.0 (9.4, 15.0)^①,④	15.0 (12.0, 15.0)^②	16.0 (12.6, 17.0)	78.504	0.000
Age of onset/year	19.0 (16.0, 24.0)	25.0 (20.0, 31.0)	‒	-7.125	0.000
Duration of illness/month	23.0 (7.5, 60.0)	6.0 (2.0, 24.0)	‒	-6.712	0.000
Number of episodes	1.0 (1.0, 1.0)	1.0 (1.0, 1.0)	‒	-0.309	0.757
TEPS total score/score	72.3±13.3^①	66.8±16.0^②,③	81.7±12.9	26.028	0.000
Anticipatory	34.0 (30.0, 38.0)^①	30.0 (24.0, 37.0)^②	37.0 (33.0, 43.0)	34.729	0.000
Abstract anticipatory	18.0 (14.0, 20.0)^①	15.0 (11.5, 19.0)^②,③	20.0 (18.0, 22.0)	51.744	0.000
Contextual anticipatory	16.0 (14.0, 19.0)	15.0 (13.0, 19.0)^②	18.0 (14.8, 21.0)	9.606	0.008
Consummatory	39.0 (34.0, 44.0)^①	38.0 (30.5, 42.5)^②	44.0 (38.8, 50.0)	34.277	0.000
Abstract consummatory	24.5±5.3^①	22.5±6.3^②,③	27.7±4.6	20.481	0.000
Contextual consummatory	14.0 (11.5, 17.0) ^①	15.0 (11.5, 16.5)^②	17.0 (14.0, 19.0)	22.299	0.000