谷氨酸通路基因多态性交互作用与快感缺失的关联研究

黄欣欣, 刘超, 吕钦谕, 胡国芹, 鲍晨曦, 张瑶, 易正辉

Relationship between polymorphic interaction of glutamate pathway genes and anhedonia

HUANG Xinxin, LIU Chao, LÜ Qinyu, HU Guoqin, BAO Chenxi, ZHANG Yao, YI Zhenghui

表2 5个候选基因的17个SNPs的信息

Tab 2 Information on the 17 SNPs for the five candidate genes

Candidate gene SNP Chromosome Position Alleles MAF Feature NOS1AP rs12742393 1q23.3 162224586 C/A 0.32 Intron2 rs1415259 162085309 C/T 0.42 Intron1 rs1415263 162166043 C/T 0.48 Intron2 rs1858232 162303838 G/A 0.33 Intron5 rs348624 162335256 C/T 0.25 Synonymous_exon9 rs6680461 162255286 G/T 0.39 Intron2 GSK3β rs334558 3q13.33 119813282 G/A 0.40 5′-flanking rs6779828 119775147 C/T 0.28 Intron1 DAOA rs3916965 13q33.2 106103360 C/T 0.36 Intergenic region rs778294 106142235 C/T 0.22 Synonymous_exon4 rs947267 106139662 G/T 0.49 Intron3 DISC1 rs1538979 1q42.2 231896868 C/T 0.24 Intron4 rs821577 232067057 G/T 0.38 Intron9 rs821633 232148933 C/T 0.41 Intron11 rs999710 232010943 G/A 0.40 Intron9 GRIN2A rs1014531 16p13.2 9855794 G/A 0.27 3′-UTR rs1420040 9850397 G/A 0.42 3′-UTR