低氧诱导的长链非编码RNA 68在肝癌中的功能及其作用机制

谭露, 沈少明, 何平

Function and mechanism study of hypoxia-induced long non-coding RNA 68 in hepatocellular carcinoma

TAN Lu, SHEN Shaoming, HE Ping

图1 低氧下HILRNA68在肝癌细胞中表达显著升高 Note：A. LncRNA microarray of SMMC-7721 exposed to hypoxia for 12 h. B. Differential lncRNA analysis of SMMC-7721 under hypoxia and normoxia. Red: up-regulated lncRNA; blue: down-regulated lncRNA. Fold change≥4, FDR≤0.05. C. Heatmap analysis of the indicated differentially expressed genes (DEGs), with data normalized using Z-score methods. N—normoxia; H—hypoxia. D. qRT-PCR analysis of indicated lncRNA in SMMC-7721 cells under normoxia and hypoxia. E. qRT-PCR analysis of HILRNA68 in human HCC cell lines (PLC/PRF/5, MHCC-97H, MHCC-97L, and Bel-7402) under normoxia and hypoxia.

Fig 1 HILRNA68 was up-regulated in HCC cells under hypoxia