结直肠癌中自然杀伤细胞表型及功能初探

冯昫皎, 刘健悦, 戚炀炀, 孙晶, 沈蕾

Phenotype and function of NK cell in colorectal cancer

FENG Xujiao, LIU Jianyue, QI Yangyang, SUN Jing, SHEN Lei

图2 肿瘤组织中NK细胞比例减少且呈现耗竭表型 Note： A. Representative flow cytometry analysis and percentage of NK cells in normal and tumor tissues (n=25). B. Representative flow cytometry analysis and percentage of CD16+NK cells in PBMC, normal and tumor tissues (nPBMC=15, nnormal=25, and nTumor=25). C. Representative flow cytometry analysis of the expression of CD27, CD69, HLA-DR and TIM-3 on NK cells in normal and tumor tissues. D. The expression levels of CD27, CD69, HLA-DR and TIM-3 on NK cells in normal and tumor tissues (n=25). ①P=0.007, ②P=0.000, ③P=0.008, ④P=0.001, ⑤P=0.024. MFI—mean fluorenscence intensity.

Fig 2 NK cells in CRC tumor tissues were reduced and showed an exhaustion phenotype