钙离子转运ATP酶B2杂合突变导致小鼠渐进性前庭功能障碍

刘祎晴, 金晨曦, 冯宝怡, 成桢哲, 孙怡琳, 郑晓飞, 董庭婷, 吴皓, 陶永

Atp2b2 Oblivion heterozygous mutation causes progressive vestibular dysfunction in mice

LIU Yiqing, JIN Chenxi, FENG Baoyi, CHENG Zhenzhe, SUN Yilin, ZHENG Xiaofei, DONG Tingting, WU Hao, TAO Yong

图1 Wt组及Obl/+组小鼠前庭椭圆囊ATP2B2表达情况及毛细胞计数 Note： A. Representative confocal images with F-actin (green) and ATP2B2 (red) stained at utricles (×1 000). Scale bar=1 μm. B. Representative confocal images with MYO7A (gray), SOX2 (red) and nuclei (blue) stained at utricles (×126). Scale bar=10 μm. C. Numbers of hair cells (HCs) in an area of 10 000 μm2 in the ES zone and the S zone.

Fig 1 Expression of ATP2B2 and hair cell count in vestibular utricles of the Wt group and the Obl/+ group mice