钙离子转运ATP酶B2杂合突变导致小鼠渐进性前庭功能障碍

刘祎晴, 金晨曦, 冯宝怡, 成桢哲, 孙怡琳, 郑晓飞, 董庭婷, 吴皓, 陶永

Atp2b2 Oblivion heterozygous mutation causes progressive vestibular dysfunction in mice

LIU Yiqing, JIN Chenxi, FENG Baoyi, CHENG Zhenzhe, SUN Yilin, ZHENG Xiaofei, DONG Tingting, WU Hao, TAO Yong

图3 Wt组及Obl/+组小鼠椭圆囊毛细胞线粒体及带状突触超微结构 Note： A/D/G/J. Ultrastructure of mitochondria under the cuticular plate in the type Ⅰ utricle hair cells. The images on the right are partial enlargements of the boxes in the left images. Scale bar=1 μm [left: 2-month (×1 500), 8-month (×2 500)] or 100 nm (right: ×15 000). B/C/E/F/H/I/K/L. Ultrastructure of mitochondria and ribbon synapses at the synaptic site in utricle hair cells. The images on the right are partial enlargements of the boxes in the left images. Scale bar=1 μm [left: 2-month (×1 500), 8-month (×2 500)] or 100 nm (right: ×15 000). The red boxes indicate mitochondria; the yellow boxes indicate ribbon synapses; the arrow indicates mitochondrion with vacuole-like denaturation.

Fig 3 Ultrastructure of mitochondria and ribbon synapses of hair cells in utricles of the Wt group and the Obl/+ group mice