两样本孟德尔随机化法分析1型糖尿病对结直肠癌的影响

俞洋, 孟丹, 仇奕文, 袁见, 朱莹杰

Analysis of impact of type 1 diabetes on colorectal cancer by using two-sample Mendelian randomization

YU Yang, MENG Dan, QIU Yiwen, YUAN Jian, ZHU Yingjie

表1 5种MR方法检验1型糖尿病对结直肠癌的效应

Tab 1 Effect of type 1 diabetes on colorectal cancer using five MR methods

Exposure Outcome MR method P value OR (95%CI) Type 1 diabetes Colorectal cancer IVW 0.003 4 1.000 7 (1.000 2‒1.001 1) MR-Egger 0.001 3 1.001 1 (1.000 5‒1.001 8) Weighted median 3.39×10-5 1.001 0 (1.000 5‒1.001 4) Simple mode 0.671 9 1.000 3 (0.998 8‒1.001 9) Weighted mode 0.000 1 1.001 0 (1.000 6‒1.001 4)