两样本孟德尔随机化法分析1型糖尿病对结直肠癌的影响

俞洋, 孟丹, 仇奕文, 袁见, 朱莹杰

Analysis of impact of type 1 diabetes on colorectal cancer by using two-sample Mendelian randomization

YU Yang, MENG Dan, QIU Yiwen, YUAN Jian, ZHU Yingjie

表2 5种MR方法检验结直肠癌对1型糖尿病的效应

Tab 2 Effect of colorectal cancer on type 1 diabetes using five MR methods

Exposure Outcome MR method P value OR (95%CI) Colorectal cancer Type 1 diabetes IVW 0.373 2 0.013 8 (1.12×10-6‒171.093 6) MR-Egger 0.643 6 0.000 3 (3.23×10-18‒2.96×10-10) Weighted median 0.273 9 0.000 8 (2.34×10-9‒279.941 3) Simple mode 0.247 1 3.36×10-6 (1.82×10-14‒745.124 1) Weighted mode 0.266 8 4.42×10-5 (4.18×10-12‒426.783 2)