靶向髓源性抑制细胞的叶酸循环增强肿瘤免疫治疗效果研究

何蕊, 颜克鹏, 王静

Targeting folate cycle enhances effects of cancer immunotherapy by modulating myeloid-derived suppressor cells

HE Rui, YAN Kepeng, WANG Jing

图1 体外诱导MDSCs高表达叶酸循环通路相关代谢酶 Note： A. Expression of PD-L1 in in vitro induced MDSCs detected by flow cytometry. B. ROS levels of in vitro induced MDSCs detected by flow cytometry. C. CD8 T cells proliferation was assessed by flow cytometry. D. One-carbon unit metabolic pathway. E?J. RNA levels of folate cycle-related metabolic enzymes [Dhfr (E), Mthfd2 (F), Shmt2 (G), Shmt1 (H), Mthfd1 (I), and Aldh1l1 (J)] in induced MDSCs detected by qRT-PCR. ①P=0.000, ②P=0.001, compared with the control group.

Fig 1 Expression of folate cycle-related metabolic enzymes in induced MDSCs in vitro