靶向髓源性抑制细胞的叶酸循环增强肿瘤免疫治疗效果研究

何蕊, 颜克鹏, 王静

Targeting folate cycle enhances effects of cancer immunotherapy by modulating myeloid-derived suppressor cells

HE Rui, YAN Kepeng, WANG Jing

图2 靶向叶酸循环抑制MDSCs的分化 Note： A/E. Cell viability of bone marrow cells treated with DS18 (A) or Pemetrexed (E) detected by flow cytometry. B/F. Percentages of CD11b+ Gr1+ cells treated with DS18 (B) or Pemetrexed (F). C/G. Absolute count of live cells treated with DS18 (C) or Pemetrexed (G). D/H. Absolute count of MDSCs treated with DS18 (D) or Pemetrexed(H). ①P= 0.008, ②P= 0.013, ③P= 0.005, compared with the control group.

Fig 2 Targeting folate cycle inhibits differentiation of MDSCs