靶向髓源性抑制细胞的叶酸循环增强肿瘤免疫治疗效果研究

何蕊, 颜克鹏, 王静

Targeting folate cycle enhances effects of cancer immunotherapy by modulating myeloid-derived suppressor cells

HE Rui, YAN Kepeng, WANG Jing

图3 靶向叶酸循环解除MDSCs的免疫抑制功能 Note： A. Proliferation of CD8+ T cells cocultured with NAC treated-MDSCs. B/C. Proliferation of CD8+ T cells cocultured with DS18-treated MDSCs (B) or Pemetrexed-treated MDSCs (C). D/H. ROS levels of DS18-treated MDSCs (D) or Pemetrexed-treated MDSCs (H) detected by flow cytometry. E/G. Quantitation of ROS Geo MFI. F/J. MitoROS levels of DS18-treated MDSCs (F) or Pemetrexed-treated MDSCs (J) detected by flow cytometry. I/K. Quantitation of MitoROS Geo MFI. ①P= 0.001, ②P= 0.024, ③P= 0.000, ④P= 0.035, compared with the control group.

Fig 3 Targeting folate cycle relieves immunosuppressive function of MDSCs