靶向髓源性抑制细胞的叶酸循环增强肿瘤免疫治疗效果研究

何蕊, 颜克鹏, 王静

Targeting folate cycle enhances effects of cancer immunotherapy by modulating myeloid-derived suppressor cells

HE Rui, YAN Kepeng, WANG Jing

图4 叶酸循环抑制剂处理后MDSCs的转录组分析 Note： A. Differentially expressed genes between DS18 and Pemetrexed-treated MDSCs, compared with the control group. B/C. Cluster analysis of differential gene groups in DS18 (B)- or Pemetrexed (C)-treated MDSCs, compared with the control group. D/E. GO enrichment analysis of differentially upregulated (D)or downregulated (E) genes in DS18-treated MDSCs (biological process). F/G. GO enrichment analysis of differentially upregulated (F) or downregulated (G) genes in Pemetrexed-treated MDSCs (biological process).

Fig 4 Transcript analysis of MDSCs after treatment with folate cycle inhibitors