PRMT6促进乳腺癌细胞的增殖和迁移

韩依杉, 徐梓淇, 陶梦玉, 范广建, 余波

PRMT6 promotes the proliferation and migration of breast cancer cells

HAN Yishan, XU Ziqi, TAO Mengyu, FAN Guangjian, YU Bo

图4 PRMT6 调控细胞周期通路 Note： A. Volcano plot of differentially expressed genes between the control and PRMT6 knockdown groups. B. KEGG analysis of differentially expressed genes between the control and PRMT6 knockdown groups. C/E. After knocking down PRMT6 in MDA-MB-231 and MCF-7 cells, transcription level of cyclin D1 in MDA-MB-231 (C) and MCF-7 cells (E) was detected by qRT-PCR. D/F. After knocking down PRMT6 in MDA-MB-231 and MCF-7 cells, expression of cyclin D1 in MDA-MB-231 (D) and MCF-7 cells (F) was detected by Western blotting. G/H. Cell cycle analysis was performed after PRMT6 knockdown in MDA-MB-231 (G) and MCF-7 cells (H).

Fig 4 Regulation of PRMT6 on the cell cycle pathway