预免疫策略结合mVenus-p27K-系统构建休眠肿瘤小鼠模型

木司塔巴·木台力甫, 王俊杰, 钱云臻, 陈溯源, 邵达, 张志刚, 李冬雪

A dormant cancer mouse model established by combining preimmune strategy with mVenus-p27K - system

MUTAILIFU Musitaba, WANG Junjie, QIAN Yunzhen, CHEN Suyuan, SHAO Da, ZHANG Zhigang, LI Dongxue

图5 在预免疫小鼠中构建休眠肿瘤小鼠模型 Note： A. Bioluminescence imaging results of subcutaneous KPC1199-PDL tumors in the untreated group and the treated group (GCV+DTX) at different time points. B. Quantitative analysis of bioluminescence imaging intensity at different time points in the untreated group and the treated group. (The dashed gray line represents the background luminescence in tumor-free mice). C. Bioluminescence imaging results of the control group and the PIM group at different time points. D. Quantitative analysis of bioluminescence imaging intensity at different time points in the control group and the PIM group. (The dashed gray line represents the background luminescence in tumor-free mice). E/F. Images of a single DCC (E) and a small cluster of DCCs (F) (×100).

Fig 5 Establishment of dormant cancer model in preimmunized mice