七氟烷对原代少突胶质细胞增殖和分化的影响

施灵玲, 程燕咏, 张磊

Effects of sevoflurane exposure on proliferation and differentiation of primary oligodendrocytes

SHI Lingling, CHENG Yanyong, ZHANG Lei

图3 多次七氟烷处理对OPC增殖能力的影响 Note： A. Immunofluorescence staining showed the expression of BrdU in OPCs. The scale bar is 100 μm. B. The number of BrdU-positive cells was normalized to the number of PDGFRα positive cells. Multiple sevoflurane exposures increased the proliferation level of PDGFRα-positive OPCs. C. Immunofluorescence staining showed the expression of Ki67 in OPCs. The scale bar is 100 μm. D. The number of Ki67-positive cells was normalized to the number of Hoechest-positive cells. Multiple sevoflurane exposures increased the proliferation level of PDGFRα-positive OPCs. ①P=0.008, ②P=0.007, compared with the control group.

Fig 3 Effects of multiple sevoflurane exposure on the proliferation of OPCs