分选链接蛋白1抑制结直肠癌细胞增殖和迁移的作用和机制研究

钱立恒, 温凯玲, 廖颖娜, 李书鑫, 聂惠贞

Study on the effect and mechanism of sorting nexin 1 on inhibiting the proliferation and migration of colorectal cancer cells

QIAN Liheng, WEN Kailing, LIAO Yingna, LI Shuxin, NIE Huizhen

图3 SNX1在CRC组织中表达情况及其与临床病理信息的相关性分析 Note： A. Expression of SNX1 detected by IHC in CRC tissues and para-carcinoma tissues from CRC patients. B. SNX1 staining was divided into four grades according to the depth of tissue microarray IHC staining. The two lower grades were grouped as the low-expression group, while the two higher grades were classified as the high-expression group. C. Expression of SNX1 was decreased in 54% of CRC tissues in tissue microarrays, by comparing IHC grades of CRC tissues with para-carcinoma tissues D. Correlation between SNX1 protein expression and age of patients in tissue microarrays. E. Correlation between SNX1 protein expression and tumor size of patients in tissue microarrays. F. Correlation between SNX1 protein expression and lymphatic invasion of patients in tissue microarrays. ①P=0.036, compared with the <60 years old group; ②P=0.005, compared with the <5 cm group; ③P=0.045, compared with the no lymphatic invasion group.

Fig 3 Expression levels of SNX1 in CRC tissues and their correlation with clinical pathological information