分选链接蛋白1抑制结直肠癌细胞增殖和迁移的作用和机制研究

钱立恒, 温凯玲, 廖颖娜, 李书鑫, 聂惠贞

Study on the effect and mechanism of sorting nexin 1 on inhibiting the proliferation and migration of colorectal cancer cells

QIAN Liheng, WEN Kailing, LIAO Yingna, LI Shuxin, NIE Huizhen

图6 SNX1 低表达与CRC转移关键基因以及EMT相关 Note： A?C. Correlation analysis between SNX1 and MACC1 (A), MET (B), NOTCH1 (C) in GSE41568 database. D/E. Relative mRNA expression of MACC1, MET and NOCTH1 in SNX1-konckdown and control groups in HT29 cells (D) and SW480 cells (E). F/G. Relative mRNA expression of CDH1, VIM and SNAI1 in SNX1-konckdown and control groups in HT29 cells (F) and SW480 cells (G). ①P=0.013, ②P=0.000, ③P=0.015, ④P=0.025, ⑤P=0.048, ⑥P=0.001, ⑦P=0.037, ⑧P=0.047, ⑨P=0.006, ⑩P=0.004, ?P=0.002, compared with the NC-siRNA group.

Fig 6 Correlation between low expression of SNX1 and key genes of CRC metastasis and EMT