肿瘤坏死因子-α在新型冠状病毒感染合并肾损伤中的作用

PANDIT Roshan, 卢君瑶, 何立珩, 包玉洁, 季萍, 陈颖盈, 许洁, 王颖

Role of tumor necrosis factor-α in coronavirus disease 2019-associated kidney injury

PANDIT Roshan, LU Junyao, HE Liheng, BAO Yujie, JI Ping, CHEN Yingying, XU Jie, WANG Ying

图3 SARS-CoV-2 S1重组蛋白体外刺激THP-1巨噬细胞产生炎症因子的水平 Note： A‒C. Fold changes in TNF-α (A), IL1-β (B) and CXCL10 (C) mRNA levels in THP-1 cells upon stimulation with S1 spike protein at a concentration of 500 ng/mL for 4 h and 8 h. D‒F. Levels of TNF-α (D), IL-1β (E) and CXCL10 (F) in the supernatants of THP-1 cells stimulated with S1 spike protein (500 ng/mL) for 4 h and 8 h. ①P<0.001, ②P=0.001, ③P=0.008, compared with the control.

Fig 3 Levels of inflammatory factors induced by SARS-CoV-2 S1 recombinant protein in THP-1 macrophages in vitro