肿瘤坏死因子-α在新型冠状病毒感染合并肾损伤中的作用

PANDIT Roshan, 卢君瑶, 何立珩, 包玉洁, 季萍, 陈颖盈, 许洁, 王颖

Role of tumor necrosis factor-α in coronavirus disease 2019-associated kidney injury

PANDIT Roshan, LU Junyao, HE Liheng, BAO Yujie, JI Ping, CHEN Yingying, XU Jie, WANG Ying

图5 HK-2细胞的炎症反应依赖于S1蛋白处理THP-1细胞产生的TNF-α Note： A. Diagram of the culture of HK-2 cells in conditioned medium with the addition of Infliximab for 24 h. Conditioned medium was obtained by stimulating THP-1 cells with S1 protein (500 ng/mL) for 8h. B. Fold changes in TNF-α mRNA levels in HK-2 cells cultured in conditioned medium with the addition of Infliximab. C. TNF-α levels in THP-1 cells stimulated with S1 spike protein and in HK-2 cells cultured in conditioned medium with or without the addition of Infliximab. ①P<0.001.

Fig 5 Dependent of Inflammatory response in HK-2 cells on TNF-α produced by S1 protein-treated THP-1 cells