复发难治性多发性骨髓瘤伴多病灶髓外浸润合并肺腺癌1例报道
杜芳, 周凌云, 陈姣, 刘丹波, 向泓先, 陈海飞

A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma
DU Fang, ZHOU Lingyun, CHEN Jiao, LIU Danbo, XIANG Hongxian, CHEN Haifei
表1 患者治疗方案
Tab 1 Patient treatment plan
Chemotherapy protocolTherapeutic efficacy
Bortezomib+cyclophosphamide+dexamethasone (BCD, 7 courses)VGPR
Bortezomib+dexamethasone+thalidomide (BDT, 3 courses)CR
Bortezomib (maintenance)
Bortezomib+thalidomide (BT, maintenance)CR
Thalidomide (maintenance)CR
Bortezomib+(R, S)-lenalidomide+dexamethasone (BRD, 3 courses)PD
Bortezomib+cyclophosphamide+dexamethasone+thalidomide (BCDT)PR
Ixazomib+dexamethasone (ID)PD
Ixazomib+pomalidomide+dexamethasone (IPD)SD
Daratumumab+pomalidomide+dexamethasone (DPD, 9 courses)PR

Resection of thoracoscopic left lower lobe and chest wall mass

(lung adenocarcinoma and multiple myeloma chest wall invasion)

PD
Daratumumab+carfilzomib+dexamethasone (DKD, 2 courses)PD
Carfilzomib+cyclophosphamide+dexamethasone (KCD, 5 courses)PR
Carfilzomib+bendamustine+dexamethasone (KBD, 2 courses)PD
Daratumumab+carfilzomib+pomalidomide+dexamethasone (DKPD)PR